职 称：讲师
学 历：博士
E-mail: yuanh113@163.com
研究方向：膜蛋白疾病及其离子通道
学习、工作经历：
2005/09-2009/07，湖北师范学院，生命科学学院，生物科学专业，学士
2009/09-2016/06，华中科技大学，生命科学与技术学院，遗传学专业，博士
2016/08-2017/03，华中科技大学，公共卫生学院，博士后
2017/04-至今，十大信誉好的平台，生物医药研究院，讲师
研究课题：
1.国家自然科学基金青年基金，32000797，PKD2乙酰化调控自身功能的分子机制及其在遗传性多囊肾发展中的作用研究，2021/01-2023，24万，在研，主持
2.湖北省自然科学基金青年基金，2019CFB166，Nav1.5结合蛋白αA-crystallin调控钠离子通道功能及其相关性心律失常疾病的机制研究，2019/01-2020/12，5万元，结题，主持
3.国家自然科学基金面上项目，31871176，PKD2的S4-S5连接域与C末端间相互作用介导的调控其离子通道功能及相关疾病的机制，2019/01-2022/12，60万，在研，参加
4.国家自然科学基金面上项目，81370206，心律失常相关基因MOG1的遗传和功能研究，2013/01-2017/12，70万元，已结题，参加
5.国家自然科学基金面上项目，81270162，心钠肽在房颤发生中的作用研究，2013/01-2016/12，80万元，已结题，参加
研究成果：
(1)Huang Yuan; Li Shi; Jia Zhenhua; Zhao Weiwei; Zhou Cefan; Zhang Rui; Declan William Ali; Marek Michalak; Chen Xing-Zhen; Tang Jingfeng, Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy. Front Oncol. 2020 Dec 4; 10:573127.
(2)Huang Yuan; Li Shunyao; Jia Zhenhua; Li Shi; He Wenzao; Zhou Cefan; Zhang Rui; Xu Rui; Sun Bo; Declan William Ali; Marek Michalak; Chen Xing-Zhen; Tang Jingfeng Tang, TRIM4 interacts with TRPM8 and regulates its channel function through K423-mediated ubiquitination. J Cell Physiol. 2020 Oct 9. doi: 10.1002/jcp.30065.
(3) Zhou Cefan; Liang Yanyan; Zhou Li; Yan Yanan; Liu Nanxi; Zhang Rui; Huang Yuan; Wang Ming; Tang Yongfei; Declan William Ali; Wang Yefu; Marek Michalak; Chen Xing-Zhen; Tang Jingfeng. TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer. Autophagy. 2020, 22:1-21.
(4) Zhou Cefan; Yi Changhua; Yi Yongxiang; Qin Wenying; Yan Yanan; Dong Xueying; Zhang Xuewen;Huang Yuan, Zhang Rui; Wei Jie; Declan William Ali; Marek Michalak; Chen Xing-Zhen; Tang Jingfeng. LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. Molecular Cancer. 2020, 29; 19(1):118.
(5) Zhou Cefan; Qian Xuehong; Hu Miao; Zhang Rui; Liu Nanxi;Huang Yuan, Yang Jing; Zhang Juan; Bai Hua; Yang Yuyan; Wang Yefu; Ali Declan; Michalak Marek; Chen Xing-Zhen; Tang Jingfeng. STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I. Autophagy. 2019 7:1-21.
(6) Huang Yuan; Yang Jiawei; Xie Wanyi; Li Qince; Zeng Zhipeng; Sui Haibo; Shan Zhonggui; Huang Zhengrong. A novel KCND3 mutation associated with early-onset lone atrial fibrillation. Oncotarget, 2017.12.29, 8(70):115503~115512.
(7) Wu, Liufeng; Meng Jia; Shen Qing; Zhang Yi; Pan Susu; Chen Zhuo; Zhu, Ling-Qiang; Lu Youming;Huang Yuan; Zhang Guo. Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice. Nat Commun, 2017.6.27, 8: 15904~15904.
(8)Huang Yuan; Wang Zhijie; Liu Yinan; Xiong Hongbo; Zhao Yuanyuan; Wu Ling; Yuan Chao; Wang Longfei; Hou Yuxi; Yu Gang; Huang Zhengrong; Xu Chengqi; Chen Qiuyun; Wang Qing K. alphaB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5. J Biol Chem, 2016.5.20, 291(21): 11030~11041.
(9) Zhao Yuanyuan;Huang Yuan; Li Weihua; Wang Zhijie; Zhan Shaopeng; Zhou Mengchen; Yao Yufeng; Zeng Zhipeng; Hou Yuxi; Chen Qiuyun; Tu, Xin; Wang, Qing K; Huang Zhengrong. Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p. Biochim Biophys Acta, 2015.10, 1852(10 Pt A): 2024~2034.
