职 称：讲师

学 历：博士

E-mail:qizhangli@hbut.edu.cn

研究方向：1. 微生物基因工程； 2. 真菌活性蛋白的免疫调节机制研究； 3. 真菌活性蛋白的抗肿瘤分子机制研究。

工作经历：

2019.11-今 十大信誉好的平台 讲师

2016.08—2019.06 中山大学 生命科学学院 博士

2012.02—2014.04 北京集佳知识产权代理有限公司 西安分公司

2010.03—2011.10 上海市粮食科学研究所

2007.09—2010.03 上海交通大学 农业与生物学院 硕士

2002.09—2006.06 西北农林科技大学 生命科学学院 学士

研究课题：

1. FIPs 介导SSAT 抑制乳腺癌细胞机制的研究, 湖北省教育厅, 自筹, 2020/01 – 2021/12;

2. FIPs介导多胺代谢抑制乳腺癌作用机制的研究, 十大信誉好的平台, 4万 2021/01 – 2022/12.

研究成果：

论文：

(1)Yan Liu, Qi-Zhang Li, Liu-Ding-Ji Li, Xuan-Wei Zhou*. Immunostimulatory effects of the intracellular polysaccharides isolated from liquid culture of Ophiocordyceps sinensis (Ascomycetes) on RAW264.7 cells via the MAPK and PI3K/Akt signaling pathways. Journal of Ethnopharmacology. 2021, 275:114130.

(2)Qi-Zhang Li#, Xin Chen#, Pei-Wen Mao, Meng-Yuan Jin, Qin Wu, Xuan-Wei Zhou*. N-Glycosylated Ganoderma lucidum immunomodulatory protein improved anti-inflammatory activity via inhibition of p38 MAPK pathway. Food & Function. 2021, 12(8): 3393-3404. (封底文章)

(3)Qi-Zhang Li, Zhi-YingWang, Qiang Zheng, Sen Liu*. Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2. Computational and Structural Biotechnology Journal. 2020, 18: 2200-2208.

(4)Ke-Di Shao, Pei-Wen Mao, Qi-Zhang Li, Liu-Ding-Ji Li, Yu-liang Wang, Xuan-Wei Zhou*. Characterization of a novel fungal immunomodulatory protein, FIP-SJ75 shuffled from Ganoderma lucidum, Flammulina velutipes and Volvariella volvacea. Food & Agricultural Immunology. 2019, 30(1): 1253-1270.

(5)Qi-Zhang Li, Yu-Zhou Chang, Zhu-Mei He*, Lei Chen*, Xuan-Wei Zhou*. Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in RAW264.7 cells. Journal of Cellular Physiology. 2019, 234(12):23337-23348.

(6)刘玲,李奇璋,周选围*,王玉亮*.重组黑芝免疫调节蛋白对小鼠巨噬细胞RAW264.7向M1型分化的影响.食品科学. 2019, 40(23): 170-175.

(7)Qi-Zhang Li, Yu-Zhang Zheng, Xuan-Wei Zhou*. Fungal immunomodulatory proteins: characteristic, potential antitumor activities and their molecular mechanisms. Drug Discovery Today. 2019, 24(1), 307-314.

(8)Qi-Zhang Li, Zhu-Mei He*. Advances in research of the structural gene characteristics of the aflatoxin biosynthetic gene cluster. Journal of Plant Science and Phytopathology. 2018, 2: 068-082.

(9)高艳华,李奇璋,刘玲,郑雨璋,周选围*.重组真菌免疫调节蛋白对巨噬细胞raw 264.7激活应答的研究.上海交通大学学报(农业科学版). 2018, 162(04): 57-62, 69.

(10)Qi-Zhang Li, Yu-Zhou Chang, Kai-Qi Su, Xiao-Lei Wang, Xiao-Hui Bai*, Xuan-Wei Zhou*. Cloning and characterization of promoters of the fungal immunomodulatory protein genes from Ganoderma spp. (Agaricomycetes) and their response to methyl jasmonate and salicylic acid. International Journal of Medicinal Mushrooms. 2018, 20(2): 177-189.

(11)Man Tang, Xiaoxia Li, Qizhang Li, Yanchao Zhou, Wen Pan, Jiayang Gao, Zi-Wei Ye, Shaoping Weng, Qiuyun Liu*, Jianguo He*, Zhumei He*. Conditional potency is a hallmark of viral protein-derived toxic peptides. Medical Hypotheses. 2017, 100: 2-3.

(12)Wei-Ran Cong, Yan Liu, Qi-Zhang Li, Xuan-Wei Zhou*. Cloning and analysis of a functional promoter of fungal immunomodulatory protein from Flammulina velutipes. Molecular Biology Reports. 2014, 41(7): 4381-4387.

(13)Wei-Ran Cong, Hui Xu, Yan Liu, Qi-Zhang Li, Wei Li*, Xuan-Wei Zhou*. Production and functional characterization of a novel fungal immunomodulatory protein FIP-SN15 shuffled from two genes of Ganoderma species. Applied Microbiology and Biotechnology. 2014, 98(13): 5967-5975.

(14)Xue-Fei Wang#, Qi-Zhang Li#, Ting-Wen Bao, Wei-Ran Cong, Wen-Xia Song, Xuan-Wei Zhou*. In vitro rapid evolution of fungal immunomodulatory proteins by DNA family shuffling. Applied Microbiology and Biotechnology. 2013, 97(6): 2455-2465.

(15)Xue-Fei Wang, Kai-Qi Su, Ting-Wen Bao, Wei-Ran Cong, Yun-Fei Chen, Qi-Zhang Li, Xuan-Wei Zhou*. Immunomodulatory effects of fungal proteins. Current Topics in Nutraceutical Research. 2012, 10(1): 1-12.

(16)Xuan-Wei Zhou, Xue-Fei Wang, Qi-Zhang Li. Expression and characteristic of the Cu/Zn superoxide dismutase gene from the insect parasitizing fungus Cordyceps militaris. Molecular Biology Reports. 2012, 39(12): 10303-10311.

(17)刘青松,王文高,丁丹华,李奇璋.膜分离纯化蛋黄卵磷脂工艺研究.粮食与油脂. 2011, 06: 20-23. (2011-06-10)

(18)曹文明,薛斌,曹洁,袁超,李奇璋.氧化甘油三酯聚合物与油脂氧化程度关联性.粮食与油脂. 2011, 04: 1-5. (2011-04-10)

(19)薛斌,曹洁,李奇璋.我国食用油脂冬化分提技术及其应用概述.粮食与油脂. 2011, 04: 12-14. (2011-04-10)

(20)Qi-Zhang Li, Lei Huang, Xue-Fei Wang, Xin-Sheng Li, San-Qiao Wu, Xuan-Wei Zhou*. Fungal immunomodulatory protein from Flammulina velutipes induces cytokine gene expression in mouse spleen cells. Current Topics in Nutraceutical Research. 2011, 9(3): 111-118.

(21)Qi-Zhang Li, Sheng-Bo Zheng, Xue-Fei Wang, Tingwen Bao, Xuanwei Zhou*. Preparation of rabbit anti-Ganoderma sinensis immunomodulatory protein polyclonal antibody. African Journal of Microbiology Research. 2011, 5(12), 1562-1564.

(22)Qi-Zhang Li, Xue-Fei Wang, Xuan-Wei Zhou*. Recent status and prospects of the fungal immunomodulatory protein family. Critical Reviews in Biotechnology. 2011, 31(4): 365-375.

(23)Qi-Zhang Li, Xue-Fei Wang, Yi-Yuan Chen, Juan Lin, Xuanwei Zhou*. Cytokines expression induced by Ganoderma sinensis fungal immunomodulatory proteins (FIP-gsi) in mouse spleen cells. Applied Biochemistry and Biotechnology. 2010, 162(5): 1403-1413.

(24)Qi-Zhang Li, Xue-Fei Wang, Ting-Wen Bao, Liang Ran, Juan Lin, Xuan-Wei Zhou*. In vitro synthsis of a recombinant fungal immunomodulatory protein from Lingzhi or Reishi medicinal mushroom, Gandoerma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) and analysis of its immunomodulatory activity. International Journal of Medicinal Mushrooms. 2010, 12(4): 347-358.

(25)李奇璋,王雪飞,黄蕾,周选围*.紫芝免疫调节蛋白基因的原核表达与功能分析.西北植物学报. 2010, 30 (1): 0035-0040.

(26)李奇璋,周选围*.农学在通识教育中的地位和作用及特殊的教育内容.安徽农业科学. 2009, 37(36): 18311-18314.

(27)Lei Huang, Qi-Zhang Li, Yi-Yuan Chen, Xue-Fei Wang, Xuan-Wei Zhou*. Determination and analysis of cordycepin and adenosine in the products of Cordyceps spp. African Journal of Microbiology Research. 2009, 3(12): 957-961.

(28)Xuan-Wei Zhou*, Min-Qi Xie, Fan Hong, Qi-Zhang Li, Juan Lin. Genomic cloning and characterization of a FIP-gsi gene encoding a fungal immunomodulatory protein from Ganoderma sinense Zhao et al. (Aphyllophoromycetideae). International Journal of Medicinal Mushrooms. 2009, 11(1):77-86.

(29)Xuan-Wei Zhou*, Qi-Zhang Li, Yi-Zhou Yin, Yi-Yuan Chen, Juan Lin*. Identification of medicinal Ganoderma species based on PCR with specific primers and PCR-RFLP. Planta Medica. 2008, 74(2): 197-200.

(30)李奇璋,黄蕾,周选围*,唐克轩. DNA改组技术及其在蛋白类药物定向进化中的应用.中国药物与临床. 2008, 8(8): 589-593.

(31)周选围*,林娟,李奇璋,尹燡周,孙小芬,唐克轩.灵芝蛋白类活性成分的研究进展.天然产物研究与开发. 2007, 019(005): 917-924.

(32)Xuan-Wei Zhou, Qi-Zhang Li, Jing-Ya Zhao, Ke-Xuan Tang*, Juan Lin, Yi-Zhou Yin. Comparison of rapid DNA extraction methods applied to PCR identification of medicinal mushroom Ganoderma spp. Preparative Biochemistry & Biotechnology. 2007, 37(4): 369-380.

专利：

(1) 李奇璋, 周选围. 真菌免疫调节蛋白基因启动子、重组载体及宿主细胞. CN101705230B.

(2) 周选围, 王雪飞, 李奇璋, 苏恺琪, 丛蔚然. 灵芝属间的重组真菌免疫调节蛋白基因、该基因编码的蛋白及其应用. CN102199202A.

(3) 周选围, 王雪飞, 李奇璋, 苏恺琪, 丛蔚然. 灵芝属内重组的真菌免疫调节蛋白基因、该基因编码的蛋白及其应用. CN102199201A.

(4) 周选围, 林娟, 李奇璋, 尹燡周, 唐克轩. 利用特异基因序列鉴别