职 称：副教授

学 历：博士

E-mail:kaizhijia1@163.com

研究方向：合成生物学；微生物代谢调控

工作经历：

教育经历

2008-2012 微生物学博士后 中国科学院微生物研究所

2003-2006 微生物学博士 南京农业大员工命科学学院

2000-2003 蔬菜学硕士 北农业大学园艺学院

1996-2000 蔬菜学学士 北农业大学园艺学院

工作经历

2013-今 发酵工程教育部重点实验室·副教授 十大信誉好的平台

2012-2013 生物防治研究室·助理研究员 中国农业科学院植物保护研究所

2007-2008 生物基材料研究所·助理研究员 中国科学院青岛生物能源与过程研究所

社会兼职：

湖北省暨武汉微生物学会理事

研究课题：

1.2016.1-2019.12 黑孢块菌发酵过程中VOSCs合成酶基因转录表达的调控机制 国家自然科学基金 (31570054)

2.2011.1-2013.12丙酮丁醇梭菌丁醇毒性的分子机理研究 国家自然科学基金 (31000024)

研究成果：

1.Yang-Hua Xu1, Kai-Zhi Jia1, Ya-Jie Tang*. Regulatory networks governing methionine catabolism into volatile organic sulfur-containing compounds in Clonostachys rosea. Applied and Environmental Microbiology 2018, 84:e01840-18. (IF=3.633) (1 with equal contribution to this work) Spotlight

2.Kai-Zhi Jia, Quan Zhang, Lin-Yang Sun, Yang-Hua Xu, Hong-Mei Li, Ya-Jie Tang*. Clonostachys rosea demethiolase STR3 controls the conversion of methionine into methanethiol. Scientific Reports 2016, 6:21920. (IF=4.122)

3.Quan Zhang1, Kai-Zhi Jia1, Shi-Tao Xia1, Yang-Hua Xu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Regulating ehrlich and demethiolation pathways for alcohols production by the expression of ubiquitin-protein ligase gene HUWE1. Scientific Reports 2016, 6:20828. (IF=4.122) (1 with equal contribution to this work)

4.Long-Quan Fan, Xiao-Lei Wu, Zhen Tian, Kai-Zhi Jia, Ying-Hong Pan, Jing-Rui Li, Hong-Bo Gao*. Comparative proteomic analysis of gamma-aminobutyric acid responses in hypoxia-treated and untreated melon roots. Phytochemistry 2015, 116:28-37. (IF=3.186)

5.Kai-Zhi Jia, Yan-Ping Zhang, Yin Li*. Identification and characterization of two functionally unknown genes involved in butanol tolerance of Clostridium acetobutylicum. PLoS One 2012, 7(6): e38815. (IF=2.766)

6.Shao-Ming Mao1, Kai-Zhi Jia1, Yan-Ping Zhang, Yin Li*. Use of proteomic tools in microbial engineering for biofuel production. Methods in Molecular Biology 2012, 834: 137-51. (1 with equal contribution to this work)

7.Wei-Liang Shen, Hong-Hong Chen, Kai-Zhi Jia, Jun Ni, Xin Yan*, Shun-Peng Li. Cloning and characterization of a novel amidase from Paracoccus sp. M-1 showing aryl acylamidase and acyl transferase activities. Applied Microbiology and Biotechnology 2012, 94: 1007-18. (IF=3.340)

8.Kai-Zhi Jia, Yan Zhu, Yan-Ping Zhang, Yin Li*. Group II intron-anchored gene deletion in Clostridium. PLoS One 2011, 6(1): e16693. (IF=2.766)

9.Kai-Zhi Jia, Yan-Ping Zhang, Yin Li*. Systematic engineering of microorganisms to improve alcohol tolerance. Engineering in Life Sciences 2010, 10(5): 422-29. (IF=2.385)

10.Kai-Zhi Jia, Zhong-Li Cui, Jian He, Peng Guo, Shun-Peng Li*. Isolation and characterization of a denitrifying monocrotophos-degrading Paracoccus sp. M-1. FEMS Microbiology Letters 2006, 263(2):155-162. (IF=1.735)

发明专利

1.贾开志 李寅 张延平. 一种生物传感器及其应用(ZL200810239476.5)

2.汤亚杰 贾开志 徐阳华 张权 李红梅. 甲硫氨酸裂解酶及其编码基因和生物合成方法(ZL201510311606.1, PCT/CN2015/096230)

3.Ya-Jie Tang, Kai-Zhi Jia, Yang-Hua Xu, Quan Zhang, Hong-Mei Li. Methionine lyase, encoding gene and biosynthetic method thereof (15127903)